Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon | Zendy

Michael Ramharter | Zendy; Matthias Schwab | Zendy; Ghyslain MomboNgoma | Zendy; Rella Zoleko Manego | Zendy; Daisy Akerey-Diop | Zendy; Arti Basra | Zendy; Jean-Rodolphe Mackanga | Zendy; Heike Würbel | Zendy; JanGeorg Wojtyniak | Zendy; Raquel González | Zendy; Ute Hofmann | Zendy; Mirjam Geditz | Zendy; PierreBlaise Matsiegui | Zendy; Peter G. Kremsner | Zendy; Clara Menéndez | Zendy; Reinhold Kerb | Zendy; Thorsten Lehr | Zendy

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Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon

Author(s) -

Michael Ramharter,

Matthias Schwab,

Ghyslain MomboNgoma,

Rella Zoleko Manego,

Daisy Akerey-Diop,

Arti Basra,

Jean-Rodolphe Mackanga,

Heike Würbel,

JanGeorg Wojtyniak,

Raquel González,

Ute Hofmann,

Mirjam Geditz,

PierreBlaise Matsiegui,

Peter G. Kremsner,

Clara Menéndez,

Reinhold Kerb,

Thorsten Lehr

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01113-18

Subject(s) - mefloquine , malaria , pharmacokinetics , medicine , pregnancy , population , obstetrics , pharmacology , chloroquine , environmental health , immunology , biology , genetics

Mefloquine was evaluated as an alternative for intermittent preventive treatment of malaria in pregnancy (IPTp) due to increasing resistance against the first-line drug sulfadoxine-pyrimethamine (SP). This study determined the pharmacokinetic characteristics of the mefloquine stereoisomers and the metabolite carboxymefloquine (CMQ) when given as IPTp in pregnant women.

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