First Linezolid-Resistant Clinical Isolates of Mycobacterium tuberculosis | Zendy

Elvira Richter | Zendy; Sabine Rüsch–Gerdes | Zendy; Doris Hillemann | Zendy

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First Linezolid-Resistant Clinical Isolates of Mycobacterium tuberculosis

Author(s) -

Elvira Richter,

Sabine Rüsch–Gerdes,

Doris Hillemann

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01113-06

Subject(s) - linezolid , mycobacterium tuberculosis , microbiology and biotechnology , tuberculosis , strain (injury) , mycobacterium , multiple drug resistance , biology , virology , drug resistance , medicine , bacteria , genetics , staphylococcus aureus , pathology , vancomycin , anatomy

Linezolid resistance was found in 4 (1.9%) of 210 multidrug-resistant Mycobacterium tuberculosis strains. The MICs of linezolid were 4 microg/ml (one strain) and 8 microg/ml (three strains). Since no mutations were detected in potential target genes, the mechanism of resistance remains unclear.

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