New Antifungal Susceptibility Test Based on Chitin Detection by Image Cytometry | Zendy

Yan Wang | Zendy; Arisandy N. Andriampamonjy | Zendy; Sébastien Bailly | Zendy; Cécile Garnaud | Zendy; Danièle Maubon | Zendy; Muriel Cornet | Zendy; Delphine Aldebert | Zendy

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New Antifungal Susceptibility Test Based on Chitin Detection by Image Cytometry

Author(s) -

Yan Wang,

Arisandy N. Andriampamonjy,

Sébastien Bailly,

Cécile Garnaud,

Danièle Maubon,

Muriel Cornet,

Delphine Aldebert

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01101-19

Subject(s) - antifungal , chitin , microbiology and biotechnology , cytometry , biology , flow cytometry , immunology , biochemistry , chitosan

The antifungal susceptibility tests used in clinical laboratories have several limitations. We developed a new test, SensiFONG, based on the detection of chitin levels after exposure to antifungal drugs. The optimal culture conditions were 30°C for 6 h for yeast strains and 26°C for 16 h for molds. The strains were exposed to a range of echinocandin or azole concentrations. Chitin was stained with calcofluor white.

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