Subacute Toxicity of Colistin Methanesulfonate in Rats: Comparison of Various Intravenous Dosage Regimens | Zendy

Stephanie Wallace | Zendy; Jian Li | Zendy; Roger L. Nation | Zendy; Craig R. Rayner | Zendy; D. A. H. Taylor | Zendy; Deborah Middleton | Zendy; Robert Milne | Zendy; Kingsley Coulthard | Zendy; John Turnidge | Zendy

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Subacute Toxicity of Colistin Methanesulfonate in Rats: Comparison of Various Intravenous Dosage Regimens

Author(s) -

Stephanie Wallace,

Jian Li,

Roger L. Nation,

Craig R. Rayner,

D. A. H. Taylor,

Deborah Middleton,

Robert Milne,

Kingsley Coulthard,

John Turnidge

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01101-07

Subject(s) - dosing , toxicity , medicine , pharmacology , regimen , colistin , biology , antibiotics , microbiology and biotechnology

The relative nephro- and neurotoxicity of colistin methanesulfonate (CMS) was investigated with rats during 7 days of intravenous administration in regimens mimicking twice- and once-daily dosing of a clinically relevant dose for humans. Histological examination revealed more-severe renal lesions with the regimen corresponding to once-daily dosing, indicating that the potential for renal toxicity may be greater with extended-interval dosing.

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