Identification of a Plasmid-Borne Resistance Gene Cluster Comprising the Resistance Genes erm (T), dfrK , and tet (L) in a Porcine Methicillin-Resistant Staphylococcus aureus ST398 Strain | Zendy

Kristina Kadlec | Zendy; Štefan Schwarz | Zendy

Open Access

Identification of a Plasmid-Borne Resistance Gene Cluster Comprising the Resistance Genes erm (T), dfrK , and tet (L) in a Porcine Methicillin-Resistant Staphylococcus aureus ST398 Strain

Author(s) -

Kristina Kadlec,

Štefan Schwarz

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01091-09

Subject(s) - plasmid , microbiology and biotechnology , tetracycline , staphylococcus aureus , biology , gene , streptococcus pyogenes , methicillin resistant staphylococcus aureus , virology , genetics , antibiotics , bacteria

A novel plasmid-borne resistance gene cluster comprising the genes erm(T) for macrolide-lincosamide-streptogramin B resistance, dfrK for trimethoprim resistance, and tet(L) for tetracycline resistance was identified in a porcine methicillin-resistant Staphylococcus aureus sequence type 398 (ST398) strain. This erm(T)-dfrK-tet(L) region was flanked by copies of the novel IS element ISSau10. The erm(T) region resembled that of Streptococcus pyogenes plasmid pRW35. The erm(T) gene of pKKS25 was expressed constitutively due to a 57-bp deletion in the erm(T) translational attenuator.

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