In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy | Zendy

Dan Roizman | Zendy; Céline Vidaillac | Zendy; Michael Givskov | Zendy; Liang Yang | Zendy

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In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy

Author(s) -

Dan Roizman,

Céline Vidaillac,

Michael Givskov,

Liang Yang

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01088-17

Subject(s) - tobramycin , biofilm , pseudomonas aeruginosa , antimicrobial , microbiology and biotechnology , imipenem , in vitro , biology , biological dispersal , antibiotics , gentamicin , medicine , antibiotic resistance , bacteria , population , biochemistry , genetics , environmental health

As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/p BAD - yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.

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