In Vitro Interactions of Antimicrobial Combinations with Fosfomycin against KPC-2-Producing Klebsiella pneumoniae and Protection of Resistance Development | Zendy

Maria Souli | Zendy; Irene Galani | Zendy; Stefanos Boukovalas | Zendy; Michael George Gourgoulis | Zendy; Zoi Chryssouli | Zendy; Kyriaki Kanellakopoulou | Zendy; Theofano Panagea | Zendy; Helen Giamarellou | Zendy

Open Access

In Vitro Interactions of Antimicrobial Combinations with Fosfomycin against KPC-2-Producing Klebsiella pneumoniae and Protection of Resistance Development

Author(s) -

Maria Souli,

Irene Galani,

Stefanos Boukovalas,

Michael George Gourgoulis,

Zoi Chryssouli,

Kyriaki Kanellakopoulou,

Theofano Panagea,

Helen Giamarellou

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01086-10

Subject(s) - fosfomycin , klebsiella pneumoniae , colistin , meropenem , microbiology and biotechnology , gentamicin , antimicrobial , biology , antibiotics , antibiotic resistance , escherichia coli , gene , biochemistry

Using time-kill methodology, we investigated the interactions of fosfomycin with meropenem or colistin or gentamicin against 17 genetically distinct Klebsiella pneumoniae clinical isolates carrying blaKPC-2. Synergy was observed with meropenem or colistin against 64.7 and 11.8% of tested isolates, while the combination with gentamicin resulted in indifference. All studied combinations showed improved bactericidal activity, compared to fosfomycin alone and prevented the development of fosfomycin resistance in 69.2, 53.8, and 81.8% of susceptible isolates, respectively.

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