Tolevamer Is Not Efficacious in the Neutralization of Cytotoxin in a Human Gut Model of Clostridium difficile Infection | Zendy

Simon D. Baines | Zendy; Jane Freeman | Zendy; Mark H. Wilcox | Zendy

Open Access

Tolevamer Is Not Efficacious in the Neutralization of Cytotoxin in a Human Gut Model of Clostridium difficile Infection

Author(s) -

Simon D. Baines,

Jane Freeman,

Mark H. Wilcox

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01085-08

Subject(s) - clostridium difficile , neutralization , microbiology and biotechnology , clostridiaceae , clostridium difficile toxin a , toxin , in vitro , clostridium , virology , biology , antibiotics , bacteria , virus , biochemistry , genetics

The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research