In Vitro Bactericidal Activity of Trimethoprim-Sulfamethoxazole Alone and in Combination with Colistin against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates | Zendy

Martha Nepka | Zendy; Efstathia Perivolioti | Zendy; Eleni Kraniotaki | Zendy; Lida Politi | Zendy; Athanassios Tsakris | Zendy; Spyros Pournaras | Zendy

Open Access

In Vitro Bactericidal Activity of Trimethoprim-Sulfamethoxazole Alone and in Combination with Colistin against Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates

Author(s) -

Martha Nepka,

Efstathia Perivolioti,

Eleni Kraniotaki,

Lida Politi,

Athanassios Tsakris,

Spyros Pournaras

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01082-16

Subject(s) - colistin , trimethoprim , sulfamethoxazole , acinetobacter baumannii , microbiology and biotechnology , carbapenem , acinetobacter , antimicrobial , antibiotics , biology , medicine , bacteria , pseudomonas aeruginosa , genetics

Trimethoprim-sulfamethoxazole alone and combined with colistin was testedin vitro against six carbapenem-resistantAcinetobacter baumannii (CRAB) clinical strains. After 24 h, at achievable serum concentrations, trimethoprim-sulfamethoxazole effectively killed all strains, while colistin killed only one strain. Trimethoprim-sulfamethoxazole plus colistin rapidly killed all strains after 6 h and for up to 24 h. Trimethoprim-sulfamethoxazole, one of the few remaining antimicrobials that still has a degree of activity, particularly combined with colistin, might represent an effective therapy for severe CRAB infections.

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