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The plasmid-mediated quinolone resistance determinant QnrS1 was identified in non-clonally relatedEnterobacter cloacae isolates in association with a transferable narrow-spectrum β-lactam resistance marker. Cloning experiments allowed the identification of a novel Ambler class A β-lactamase, named LAP-1. It shares 62 and 61% amino acid identity with the most closely related β-lactamases, TEM-1 and SHV-1, respectively. It has a narrow-spectrum hydrolysis of β-lactams and is strongly inhibited by clavulanic acid and sulbactam and, to a lesser extent, by tazobactam. Association of thebla LAP-1 gene with theqnrS1 gene was identified inE. cloacae isolates from France and Vietnam. These genes were plasmid located and associated with similar insertion sequences but were not associated withsul1 -type class 1 integrons, as opposed to theqnrA genes.

Novel Ambler Class A β-Lactamase LAP-1 and Its Association with the Plasmid-Mediated Quinolone Resistance Determinant QnrS1