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Plazomicin is a novel aminoglycoside with potentin vitro activity against multidrug- and carbapenem-resistantEnterobacteriaceae . The objective of this study was to assess the efficacy of plazomicin exposure, alone and in combination with meropenem or tigecycline, againstEnterobacteriaceae in the immunocompetent murine septicemia model.

antimicrobial agents and chemotherapy

<i>In Vivo</i> Efficacy of Plazomicin Alone or in Combination with Meropenem or Tigecycline against Enterobacteriaceae Isolates Exhibiting Various Resistance Mechanisms in an Immunocompetent Murine Septicemia Model