Incidence and Characteristics of Vancomycin Nonsusceptible Strains of Methicillin-Resistant Staphylococcus aureus at Hershey Medical Center | Zendy

Klaudia Kosowska-Shick | Zendy; Lois M. Ednie | Zendy; Pamela McGhee | Zendy; Kathy Smith | Zendy; Cynthia D. Todd | Zendy; Amanda Wehler | Zendy; Peter C. Appelbaum | Zendy

Open Access

Incidence and Characteristics of Vancomycin Nonsusceptible Strains of Methicillin-Resistant Staphylococcus aureus at Hershey Medical Center

Author(s) -

Klaudia Kosowska-Shick,

Lois M. Ednie,

Pamela McGhee,

Kathy Smith,

Cynthia D. Todd,

Amanda Wehler,

Peter C. Appelbaum

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01073-08

Subject(s) - etest , vancomycin , teicoplanin , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , incidence (geometry) , medicine , micrococcaceae , antibacterial agent , biology , antibiotics , bacteria , genetics , physics , optics

All 982 methicillin-resistantStaphylococcus aureus strains collected from August 2006 to December 2007 were tested for vancomycin susceptibility by using 3-μg/ml vancomycin brain heart infusion screening plates, a vancomycin Etest, and a vancomycin/teicoplanin macro Etest. Three vancomycin-intermediateStaphylococcus aureus (VISA) (0.3%) and two heterogeneous VISA (0.2%) isolates were identified. The screening method yielded 895 cases of ≤1 colony and 87 positive results (with growth of >1 colony after 48 h); further Etests showed 82/87 isolates with growth on screening plates to be false positive. Repeat testing showed a false-positivity rate of only 15 of the original 87 isolates by plate screening.

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