The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis | Zendy

Nathan P. Wiederhold | Zendy; Laura K. Najvar | Zendy; Edward P. Garvey | Zendy; Stephen Brand | Zendy; Xin Xu | Zendy; Elizabeth A. Ottinger | Zendy; Asaf Alimardanov | Zendy; Jim Cradock | Zendy; Mark L. Behnke | Zendy; William J. Hoekstra | Zendy; Robert J. Schotzinger | Zendy; Rosie Jaramillo | Zendy; Marcos Olivo | Zendy; William R. Kirkpatrick | Zendy; Thomas F. Patterson | Zendy

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The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis

Author(s) -

Nathan P. Wiederhold,

Laura K. Najvar,

Edward P. Garvey,

Stephen Brand,

Xin Xu,

Elizabeth A. Ottinger,

Asaf Alimardanov,

Jim Cradock,

Mark L. Behnke,

William J. Hoekstra,

Robert J. Schotzinger,

Rosie Jaramillo,

Marcos Olivo,

William R. Kirkpatrick,

Thomas F. Patterson

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01071-18

Subject(s) - cryptococcal meningitis , meningitis , cryptococcus neoformans , cryptococcus , cryptococcosis , microbiology and biotechnology , medicine , mycosis , fungi imperfecti , antifungal , fungus , biology , immunology , surgery , human immunodeficiency virus (hiv) , viral disease , botany

Cryptococcal meningitis is a significant cause of morbidity and mortality in immunocompromised patients. VT-1129 is a novel fungus-specific Cyp51 inhibitor with potentin vitro activity againstCryptococcus species.

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