Open AccessEmergence and Dissemination of Enterobacteriaceae Isolates Producing CTX-M-1-Like Enzymes in Spain Are Associated with IncFII (CTX-M-15) and Broad-Host-Range (CTX-M-1, -3, and -32) Plasmids
Author(s) -
Ângela Novais,
Rafael Cantón,
Raquel Moreira,
Luı́sa Peixe,
Fernando Baquero,
Teresa M. Coque
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01070-06
Subject(s) - plasmid , enterobacteriaceae , biology , host (biology) , enzyme , range (aeronautics) , microbiology and biotechnology , genetics , gene , escherichia coli , biochemistry , materials science , composite material
The spread of CTX-M-1-like enzymes in Spain is associated with particular plasmids of broad-host-range IncN (bla CTX-M-32 ,bla CTX-M-1 ), IncL/M (bla CTX-M-1 ), and IncA/C2 (bla CTX-M-3 ) or narrow-host-range IncFII (bla CTX-M-15 ). The identical genetic surroundings ofbla CTX-M-32 andbla CTX-M-1 and their locations on related 40-kb IncN plasmids indicate the in vivo evolution of this element.