Biofilms Formed by Isolates from Recurrent Vulvovaginal Candidiasis Patients Are Heterogeneous and Insensitive to Fluconazole | Zendy

Leighann Sherry | Zendy; Ryan Kean | Zendy; Emily McKloud | Zendy; Lindsay E. O’Donnell | Zendy; Rebecca Metcalfe | Zendy; B Jones | Zendy; Gordon Ramage | Zendy

Open Access

Biofilms Formed by Isolates from Recurrent Vulvovaginal Candidiasis Patients Are Heterogeneous and Insensitive to Fluconazole

Author(s) -

Leighann Sherry,

Ryan Kean,

Emily McKloud,

Lindsay E. O’Donnell,

Rebecca Metcalfe,

B Jones,

Gordon Ramage

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01065-17

Subject(s) - fluconazole , biofilm , vulvovaginal candidiasis , antifungal , microbiology and biotechnology , epidemiology , invasive candidiasis , mycosis , medicine , biology , immunology , bacteria , genetics

Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC in a patient cohort to identify the causative organisms associated with VVC. Biofilm-forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm-forming capacity, which is associated with altered antifungal drug sensitivity.

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