Polyphenols Reduce Gastritis Induced by Helicobacter pylori Infection or VacA Toxin Administration in Mice | Zendy

Paolo Ruggiero | Zendy; Francesco Tombola | Zendy; Giacomo Rossi | Zendy; Laura Pancotto | Zendy; L. Lauretti | Zendy; Giuseppe Del Giudice | Zendy; Mario Zoratti | Zendy

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Polyphenols Reduce Gastritis Induced by Helicobacter pylori Infection or VacA Toxin Administration in Mice

Author(s) -

Paolo Ruggiero,

Francesco Tombola,

Giacomo Rossi,

Laura Pancotto,

L. Lauretti,

Giuseppe Del Giudice,

Mario Zoratti

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01042-05

Subject(s) - toxin , gastritis , helicobacter pylori , microbiology and biotechnology , spirillaceae , oral administration , polyphenol , helicobacter , biology , medicine , pharmacology , gastroenterology , biochemistry , antioxidant

Helicobacter pylori colonizes the human gastric mucosa, causing inflammation that leads to atrophic gastritis, and it can cause peptic ulcer and gastric cancer. We show that polyphenol administration to mice experimentally infected byH. pylori or treated with VacA toxin can limit gastric epithelium damage, an effect that may be linked to VacA inhibition.

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