Biochemical Characterization of Metallo-β-Lactamase VIM-11 from a Pseudomonas aeruginosa Clinical Strain | Zendy

Patricia Marchiaro | Zendy; Pablo E. Tomatis | Zendy; María Alejandra Mussi | Zendy; Fernando Pasterán | Zendy; Alejandro M. Viale | Zendy; Adriana S. Limansky | Zendy; Alejandro J. Vila | Zendy

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Biochemical Characterization of Metallo-β-Lactamase VIM-11 from a Pseudomonas aeruginosa Clinical Strain

Author(s) -

Patricia Marchiaro,

Pablo E. Tomatis,

María Alejandra Mussi,

Fernando Pasterán,

Alejandro M. Viale,

Adriana S. Limansky,

Alejandro J. Vila

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01025-07

Subject(s) - pseudomonas aeruginosa , strain (injury) , microbiology and biotechnology , pseudomonadales , pseudomonadaceae , biology , bacteria , genetics , anatomy

A detailed biochemical characterization of the Pseudomonas aeruginosa VIM-11 metallo-beta-lactamase (MbetaL) is reported. The only substitution differentiating VIM-11 from VIM-2 (N165S) promoted a slightly improved catalytic efficiency of the former on 3 out of 12 substrates, notably the bulky cephalosporins. Thus, MbetaL-mediated resistance also may be modulated by remote mutations.

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