Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (Group B Streptococcus), Haemophilus ducreyi , and Vaginal Lactobacillus by 3- O -Octyl- sn -Glycerol | Zendy

Bernard J. Moncla | Zendy; Kara Pryke | Zendy; Charles E. Isaacs | Zendy

Open Access

Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (Group B Streptococcus), Haemophilus ducreyi , and Vaginal Lactobacillus by 3- O -Octyl- sn -Glycerol

Author(s) -

Bernard J. Moncla,

Kara Pryke,

Charles E. Isaacs

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01023-07

Subject(s) - neisseria gonorrhoeae , microbiology and biotechnology , streptococcus agalactiae , haemophilus ducreyi , streptococcus , haemophilus , haemophilus influenzae , lactobacillus , streptococcaceae , biology , antibiotics , bacteria , pasteurellaceae , genetics

The microbicide candidate octylglycerol inactivates sexually transmitted bacterial pathogens at concentrations which spare normal vaginal flora (lactobacillus). Standard minimum microbicidal concentration assays and time-kill assays revealed the drug concentrations and times required for inactivation. Octylglycerol concentrations must exceed the binding capacity of any human serum albumin to be effective.

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