Coordinate Hyperproduction of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia | Zendy

Virginia C. Gould | Zendy; Aki Okazaki | Zendy; Matthew B. Avison | Zendy

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Coordinate Hyperproduction of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia

Author(s) -

Virginia C. Gould,

Aki Okazaki,

Matthew B. Avison

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01020-12

Subject(s) - efflux , stenotrophomonas maltophilia , microbiology and biotechnology , minocycline , ciprofloxacin , levofloxacin , biology , aminoglycoside , drug resistance , tetracycline , antibiotics , bacteria , pseudomonas aeruginosa , genetics

A Stenotrophomonas maltophilia mutant that coordinately hyper-expresses three resistance nodulation division-type efflux pump genes, smeZ, smeJ, and smeK, has been identified. SmeZ is responsible for elevating aminoglycoside MICs; SmeJ and SmeK are jointly responsible for elevating tetracycline, minocycline, and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate with this same phenotype was identified from a sample of six, and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings.

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