Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity
Author(s) -
Seong Won Choi,
Yuexi Gu,
Ryan Peters,
Padmini Salgame,
Jerrold J. Ellner,
Graham S. Timmins,
Vojo Deretić
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01019-18
Subject(s) - antimycobacterial , ambroxol , autophagy , mycobacterium tuberculosis , tuberculosis , antibiotics , antimicrobial , microbiology and biotechnology , pharmacology , mycobacterium avium complex , medicine , chemotherapy , biology , apoptosis , pathology , biochemistry , anesthesia
Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed atMycobacterium tuberculosis . Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs.
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