Open AccessIn Vitro Antibacterial Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457
Author(s) -
Barbara D. Foleno,
Darren Abbanat,
Raúl Goldschmidt,
Robert K. Flamm,
Steve D. Paget,
Glenda C. Webb,
Ellyn Wira,
Mark J. Macielag,
Karen Bush
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01017-06
Subject(s) - linezolid , potency , in vitro , microbiology and biotechnology , antibacterial agent , pharmacology , chemistry , staphylococcus aureus , antibiotics , biology , bacteria , biochemistry , vancomycin , genetics
RWJ-416457, an investigational pyrrolopyrazolyl-substituted oxazolidinone, inhibited the growth of linezolid-susceptible staphylococci, enterococci, and streptococci at concentrations of ≤4 μg/ml, generally exhibiting two- to fourfold-greater potency than that of linezolid. Time-kill studies demonstrated bacteriostatic effects for both RWJ-416457 and linezolid.