In Vitro Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis | Zendy

Lloyd Tanner | Zendy; Joanna C. Evans | Zendy; Ronnett Seldon | Zendy; Audrey Jordaan | Zendy; Digby F. Warner | Zendy; Richard K. Haynes | Zendy; Christopher J. Parkinson | Zendy; Lubbe Wiesner | Zendy

Open Access

In Vitro Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis

Author(s) -

Lloyd Tanner,

Joanna C. Evans,

Ronnett Seldon,

Audrey Jordaan,

Digby F. Warner,

Richard K. Haynes,

Christopher J. Parkinson,

Lubbe Wiesner

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01010-19

Subject(s) - adme , mycobacterium tuberculosis , pharmacology , pharmacokinetics , in vivo , tuberculosis , clofazimine , in vitro , drug , medicine , chemistry , microbiology and biotechnology , biology , immunology , biochemistry , pathology , leprosy

Mycobacterium tuberculosis , the causative agent of tuberculosis, remains a leading infectious killer globally, demanding the urgent development of faster-acting drugs with novel mechanisms of action. Riminophenazines such as clofazimine are clinically efficacious against both drug-susceptible and drug-resistant strains ofM. tuberculosis .

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