Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients | Zendy

Emily L. Heil | Zendy; David P. Nicolau | Zendy; Andras Farkas | Zendy; Jason A. Roberts | Zendy; Kerri A. Thom | Zendy

Open Access

Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients

Author(s) -

Emily L. Heil,

David P. Nicolau,

Andras Farkas,

Jason A. Roberts,

Kerri A. Thom

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01008-18

Subject(s) - cefepime , meropenem , piperacillin/tazobactam , pharmacodynamics , dosing , pharmacokinetics , medicine , piperacillin , pharmacology , tazobactam , antibiotics , intensive care medicine , imipenem , biology , microbiology and biotechnology , antibiotic resistance , genetics , bacteria , pseudomonas aeruginosa

This was a prospective study to determine if pharmacokinetic/pharmacodynamic (PK/PD)-based antibiotic dosing software aids in achieving concentration targets in critically ill patients receiving cefepime (n = 10), meropenem (n = 20), or piperacillin-tazobactam (n = 19). Antibiotic calculator doses targeting a >90% probability of target attainment (PTA) differed from package insert doses for 22.4% (11/49) of patients.

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