Open AccessHuman Immunodeficiency Virus Types 1 and 2 Exhibit Comparable Sensitivities to Zidovudine and Other Nucleoside Analog Inhibitors In Vitro
Author(s) -
Robert A. Smith,
Geoffrey S. Gottlieb,
Donovan J. Anderson,
Crystal L. Pyrak,
Bradley D. Preston
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01004-07
Subject(s) - zidovudine , nucleoside analogue , nucleoside , reverse transcriptase , virology , in vitro , nucleotidyltransferase , virus , human immunodeficiency virus (hiv) , biology , viral disease , rna , biochemistry , gene
Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3′-azido-3′-deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.