The TetR Family Transcription Factor MAB_2299c Regulates the Expression of Two Distinct MmpS-MmpL Efflux Pumps Involved in Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus | Zendy

Ana Victoria Gutiérrez | Zendy; Matthias Richard | Zendy; Françoise Roquet-Banères | Zendy; Albertus Viljoen | Zendy; Laurent Kremer | Zendy

Open Access

The TetR Family Transcription Factor MAB_2299c Regulates the Expression of Two Distinct MmpS-MmpL Efflux Pumps Involved in Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus

Author(s) -

Ana Victoria Gutiérrez,

Matthias Richard,

Françoise Roquet-Banères,

Albertus Viljoen,

Laurent Kremer

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01000-19

Subject(s) - clofazimine , bedaquiline , mycobacterium abscessus , efflux , tetr , microbiology and biotechnology , antibiotics , mycobacterium tuberculosis , medicine , tuberculosis , immunology , biology , mycobacterium , transcription factor , pathology , leprosy , gene , genetics , repressor

Mycobacterium abscessus is a human pathogen responsible for severe respiratory infections, particularly in patients with underlying lung disorders. Notorious for being highly resistant to most antimicrobials, new therapeutic approaches are needed to successfully treatM. abscessus -infected patients. Clofazimine (CFZ) and bedaquiline (BDQ) are two antibiotics used for the treatment of multidrug-resistant tuberculosis and are considered alternatives for the treatment ofM. abscessus pulmonary disease.

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