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Relebactam is a novel class A/C β-lactamase inhibitor that restores imipenemin vitro activity against multidrug-resistant and carbapenem-nonsusceptiblePseudomonas aeruginosa . Time-kill analyses were performed to evaluate the potential role of imipenem-relebactam in combination with amikacin or colistin againstP. aeruginosa . Ten clinicalP. aeruginosa isolates (9 imipenem nonsusceptible) with imipenem-relebactam MICs ranging from 1/4 to 8/4 μg/ml were included.

In Vitro Activity of Imipenem-Relebactam Alone or in Combination with Amikacin or Colistin against Pseudomonas aeruginosa