Spore Germination as a Target for Antifungal Therapeutics | Zendy

Sébastien C. Ortiz | Zendy; Mingwei Huang | Zendy; Christina M. Hull | Zendy

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Spore Germination as a Target for Antifungal Therapeutics

Author(s) -

Sébastien C. Ortiz,

Mingwei Huang,

Christina M. Hull

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00994-19

Subject(s) - spore germination , spore , germination , microbiology and biotechnology , biology , pentamidine , cryptococcus neoformans , pharmacology , medicine , pneumonia , botany

Spores are required for long-term survival of many organisms, including most fungi. For the majority of fatal human fungal pathogens, spore germination is the key process required to initiate vegetative growth and ultimately cause disease. Because germination is required for pathogenesis, the process could hold fungus-specific targets for new antifungal drug development.

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