Open AccessIn Vivo Activity of a Novel Anti-Methicillin-Resistant Staphylococcus aureus Cephalosporin, Ceftaroline, against Vancomycin-Susceptible and -Resistant Enterococcus faecalis Strains in a Rabbit Endocarditis Model: a Comparative Study with Linezolid and Vancomycin
Author(s) -
Cédric Jacqueline,
Jocelyne Caillon,
Virginie Le Mabecque,
Anne-Françoise Miégeville,
Yigong Ge,
Donald Biek,
Éric Batard,
G. Potel
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00984-09
Subject(s) - enterococcus faecalis , linezolid , vancomycin , microbiology and biotechnology , cephalosporin , staphylococcus aureus , methicillin resistant staphylococcus aureus , enterococcus , in vivo , daptomycin , antibacterial agent , antibiotics , medicine , biology , bacteria , genetics
We assessed the in vitro and in vivo efficacy of the novel parenteral broad-spectrum cephalosporin ceftaroline againstEnterococcus faecalis in time-kill experiments and in a rabbit endocarditis model with simulated human dosing. Ceftaroline was more active than either vancomycin or linezolid against vancomycin-sensitive and -resistant isolates ofE .faecalis .