Correlation of Checkerboard Synergy Testing with Time-Kill Analysis and Clinical Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Respiratory Infections | Zendy

Derek N. Bremmer | Zendy; Karri A. Bauer | Zendy; Stephanie M. Pouch | Zendy; Keelie Thomas | Zendy; Debra S. Smith | Zendy; Debra A. Goff | Zendy; Preeti Pancholi | Zendy; Joan-Miquel Balada-Llasat | Zendy

Open Access

Correlation of Checkerboard Synergy Testing with Time-Kill Analysis and Clinical Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Respiratory Infections

Author(s) -

Derek N. Bremmer,

Karri A. Bauer,

Stephanie M. Pouch,

Keelie Thomas,

Debra S. Smith,

Debra A. Goff,

Preeti Pancholi,

Joan-Miquel Balada-Llasat

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00981-16

Subject(s) - acinetobacter baumannii , checkerboard , medicine , respiratory system , drug resistance , acinetobacter , drug , microbiology and biotechnology , biology , antibiotics , pharmacology , bacteria , pseudomonas aeruginosa , genetics

We tested 76 extensively drug-resistant (XDR) Acinetobacter baumannii isolates by the checkerboard method using only wells containing serum-achievable concentrations (SACs) of drugs. Checkerboard results were correlated by time-kill assay and clinical outcomes. Minocycline-colistin was the best combination in vitro, as it inhibited growth in one or more SAC wells in all isolates. Patients who received a combination that inhibited growth in one or more SAC wells demonstrated better microbiological clearance than those who did not (88% versus 30%; P = 0.025). The checkerboard platform may have clinical utility for XDR A. baumannii infections.

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