Open AccessIn Vitro Activities of a Wide Panel of Antifungal Drugs against Various Scopulariopsis and Microascus Species
Author(s) -
Magdalena Skóra,
Małgorzata Bulanda,
Tomasz Jagielski
Publication year - 2015
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00978-15
Subject(s) - caspofungin , terbinafine , miconazole , posaconazole , itraconazole , voriconazole , ketoconazole , pharmacology , fluconazole , amphotericin b , antifungal , in vitro , chemistry , microbiology and biotechnology , medicine , biology , biochemistry
The in vitro activities of 11 antifungal drugs against 68 Scopulariopsis and Microascus strains were investigated. Amphotericin B, 5-fluorocytosine, fluconazole, itraconazole, ketoconazole, miconazole, posaconazole, voriconazole, and ciclopirox showed no or poor antifungal effect. The best activities were exhibited by terbinafine and caspofungin, where the MIC and MEC (minimal effective concentration) ranges were 0.0313 to >16 μg/ml and 0.125 to 16 μg/ml, respectively. The MIC and MEC modes were both 1 µg/ml for terbinafine and caspofungin; the MIC50 and MEC50 were 1 µg/ml for both drugs, whereas the MIC90 and MEC90 were 4 µg/ml and 16 µg/ml, respectively.
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