Open AccessDecline in Sulfadoxine-Pyrimethamine-Resistant Alleles after Change in Drug Policy in the Amazon Region of Peru
Author(s) -
Zhansong Zhou,
Sean M. Griffing,
Alexandre Macedo de Oliveira,
Andrea M. McCollum,
Wilmer Marquiño Quezada,
Nancy Arróspide,
Ananías A. Escalante,
Venkatachalam Udhayakumar
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00975-07
Subject(s) - dhps , sulfadoxine , sulfadoxine/pyrimethamine , malaria , amazon rainforest , allele , plasmodium falciparum , biology , pyrimethamine , genetics , drug resistance , amazon basin , virology , gene , immunology , ecology
The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% fordhfr and 0% fordhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment forPlasmodium falciparum malaria. Microsatellite analysis showed that thedhfr anddhps alleles are of common origin.