Open AccessFirst Characterization of Fluoroquinolone Resistance in Streptococcus suis
Author(s) -
José Antonio Escudero,
Álvaro San Millán,
Ana Catalán,
Adela G. de la Campa,
Estefania Rivero,
Gemma Muñoz-Alonso López,
Lucas Domı́nguez,
Miguel A. Moreno,
Bruno GonzálezZorn
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00972-06
Subject(s) - streptococcus suis , microbiology and biotechnology , biology , quinolone , point mutation , gene , bacteria , genetics , horizontal gene transfer , drug resistance , mutation , genome , antibiotics , virulence
We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistantStreptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria.