Multilocus Sequence Typing Reveals Genetic Diversity of Carbapenem- or Ceftazidime-Nonsusceptible Pseudomonas aeruginosa in China | Zendy

Jingshu Ji | Zendy; Jie Wang | Zendy; Zhihui Zhou | Zendy; Haiping Wang | Zendy; Yan Jiang | Zendy; Yunsong Yu | Zendy

Open Access

Multilocus Sequence Typing Reveals Genetic Diversity of Carbapenem- or Ceftazidime-Nonsusceptible Pseudomonas aeruginosa in China

Author(s) -

Jingshu Ji,

Jie Wang,

Zhihui Zhou,

Haiping Wang,

Yan Jiang,

Yunsong Yu

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00970-13

Subject(s) - multilocus sequence typing , pseudomonas aeruginosa , biology , meropenem , ceftazidime , microbiology and biotechnology , genetic diversity , genetics , imipenem , clone (java method) , carbapenem , allele , sequence (biology) , ceftazidime/avibactam , typing , genotype , gene , antibiotic resistance , antibiotics , bacteria , medicine , population , environmental health

It is unclear whether the genetic background of drug-resistant Pseudomonas aeruginosa was disseminated from a certain clone. Thus, we performed MLST (multilocus sequence typing) of 896 P. aeruginosa isolates that were nonsusceptible to imipenem, meropenem, or ceftazidime. This revealed 254 sequence types (STs), including 104 new STs and 34 STs with novel alleles. Thirty-three clonal complexes and 404 singletons were found. In conclusion, drug-resistant P. aeruginosa clones can be developed from diverse genetic backgrounds.

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