mcr-9 , an Inducible Gene Encoding an Acquired Phosphoethanolamine Transferase in Escherichia coli, and Its Origin | Zendy

Nicolas Kieffer | Zendy; Guilhem Royer | Zendy; JeanWinoc Decousser | Zendy; Anne-Sophie Bourrel | Zendy; Mattia Palmieri | Zendy; José Manuel Ortiz de la Rosa | Zendy; Hervé Jacquier | Zendy; Érick Denamur | Zendy; Patrice Nordmann | Zendy; Laurent Poirel | Zendy

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mcr-9 , an Inducible Gene Encoding an Acquired Phosphoethanolamine Transferase in Escherichia coli, and Its Origin

Author(s) -

Nicolas Kieffer,

Guilhem Royer,

JeanWinoc Decousser,

Anne-Sophie Bourrel,

Mattia Palmieri,

José Manuel Ortiz de la Rosa,

Hervé Jacquier,

Érick Denamur,

Patrice Nordmann,

Laurent Poirel

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00965-19

Subject(s) - escherichia coli , enterobacteriaceae , mcr 1 , plasmid , biology , gene , colistin , microbiology and biotechnology , transferase , clone (java method) , genetics , enzyme , biochemistry , antibiotics

The plasmid-locatedmcr-9 gene, encoding a putative phosphoethanolamine transferase, was identified in a colistin-resistant human fecalEscherichia coli strain belonging to a very rare phylogroup, the D-ST69-O15:H6 clone. This MCR-9 protein shares 33% to 65% identity with the other plasmid-encoded MCR-type enzymes identified (MCR-1 to -8) that have been found as sources of acquired resistance to polymyxins inEnterobacteriaceae .

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