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The plasmid-locatedmcr-9 gene, encoding a putative phosphoethanolamine transferase, was identified in a colistin-resistant human fecalEscherichia coli strain belonging to a very rare phylogroup, the D-ST69-O15:H6 clone. This MCR-9 protein shares 33% to 65% identity with the other plasmid-encoded MCR-type enzymes identified (MCR-1 to -8) that have been found as sources of acquired resistance to polymyxins inEnterobacteriaceae .

mcr-9 , an Inducible Gene Encoding an Acquired Phosphoethanolamine Transferase in Escherichia coli, and Its Origin