Population Pharmacokinetics of Fluconazole in Premature Infants with Birth Weights Less than 750 Grams | Zendy

Jeremiah D. Momper | Zendy; Edmund V. Capparelli | Zendy; Kelly C. Wade | Zendy; Anand Kantak | Zendy; Ramasubbareddy Dhanireddy | Zendy; James J. Cummings | Zendy; Jonathan Nedrelow | Zendy; Mark L. Hudak | Zendy; Gratias Mundakel | Zendy; Girija Natarajan | Zendy; Jamie Gao | Zendy; Matt Laughon | Zendy; P. Brian Smith | Zendy; Daniel K. Benjamin | Zendy

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Population Pharmacokinetics of Fluconazole in Premature Infants with Birth Weights Less than 750 Grams

Author(s) -

Jeremiah D. Momper,

Edmund V. Capparelli,

Kelly C. Wade,

Anand Kantak,

Ramasubbareddy Dhanireddy,

James J. Cummings,

Jonathan Nedrelow,

Mark L. Hudak,

Gratias Mundakel,

Girija Natarajan,

Jamie Gao,

Matt Laughon,

P. Brian Smith,

Daniel K. Benjamin

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00963-16

Subject(s) - fluconazole , nonmem , pharmacokinetics , population , medicine , bioavailability , creatinine , birth weight , renal function , dosing , physiology , pharmacology , biology , pregnancy , antifungal , environmental health , dermatology , genetics

Fluconazole is an effective agent for prophylaxis of invasive candidiasis in premature infants. The objective of this study was to characterize the population pharmacokinetics (PK) and dosing requirements of fluconazole in infants with birth weights of 2,000 ng/ml in 80% of simulated infants at week 1 and 59% at week 4 of treatment. Developmental changes in fluconazole clearance are best predicted by serum creatinine in this population. A twice-weekly dose of 6 mg/kg achieves appropriate levels for prevention of invasive candidiasis in extremely premature infants.

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