rmtD2 , a New Allele of a 16S rRNA Methylase Gene, Has Been Present in Enterobacteriaceae Isolates from Argentina for More than a Decade | Zendy

Nathalie Tijet | Zendy; Patricia Andrés | Zendy; Catherine Chung | Zendy; Celeste Lucero | Zendy; Donald E. Low | Zendy; Marcelo Galas | Zendy; Alejandra Corso | Zendy; Alejandro Petroni | Zendy; Roberto G. Melano | Zendy

Open Access

rmtD2 , a New Allele of a 16S rRNA Methylase Gene, Has Been Present in Enterobacteriaceae Isolates from Argentina for More than a Decade

Author(s) -

Nathalie Tijet,

Patricia Andrés,

Catherine Chung,

Celeste Lucero,

Donald E. Low,

Marcelo Galas,

Alejandra Corso,

Alejandro Petroni,

Roberto G. Melano

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00962-10

Subject(s) - enterobacteriaceae , biology , microbiology and biotechnology , allele , 16s ribosomal rna , genetics , gene , enterobacteriaceae infections , methyltransferase , ribosomal rna , escherichia coli , methylation

The first allele of a 16S rRNA methyltransferase gene, rmtD2, conferring very high resistance to all clinically available aminoglycosides, was detected in 7/1,064 enterobacteria collected in 2007. rmtD2 was located on a conjugative plasmid in a Tn2670-like element inside a structure similar to that of rmtD1 but probably having an independent assembly. rmtD2 has been found since 1996 to 1998 mainly in Enterobacter and Citrobacter isolates, suggesting a possible reservoir in these genera. This presumption deserves monitoring by continuous surveillance.

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