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Assessment of the In Vivo Efficacy of WCK 5222 (Cefepime-Zidebactam) against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Murine Lung Infection Model
Author(s) -
Lindsay M. Avery,
Kamilia Abdelraouf,
David P. Nicolau
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00948-18
Subject(s) - cefepime , acinetobacter baumannii , medicine , in vivo , acinetobacter , microbiology and biotechnology , imipenem , biology , antibiotics , pseudomonas aeruginosa , bacteria , antibiotic resistance , genetics
We evaluated thein vivo efficacy of human-simulated WCK 5222 (cefepime-zidebactam) against cefepime-resistantAcinetobacter baumannii strains (n = 13) in the neutropenic murine lung infection model. Twelve isolates were meropenem resistant.

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