Emergence of ileS2 -Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis | Zendy

PakLeung Ho | Zendy; Chunjiao Liu | Zendy; KinHung Chow | Zendy; Cindy WingSze Tse | Zendy; Wai-U Lo | Zendy; SiuKa Mak | Zendy; Wai-Kei Lo | Zendy

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Emergence of ileS2 -Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis

Author(s) -

PakLeung Ho,

Chunjiao Liu,

KinHung Chow,

Cindy WingSze Tse,

Wai-U Lo,

SiuKa Mak,

Wai-Kei Lo

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00948-16

Subject(s) - plasmid , staphylococcus lugdunensis , biology , multiple drug resistance , microbiology and biotechnology , clone (java method) , mupirocin , staphylococcus , gene , virology , drug resistance , genetics , staphylococcus aureus , methicillin resistant staphylococcus aureus , bacteria

Of 137Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediatedileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomalileS gene. All but one of theileS2 -positive isolates belong to the predominating clone HKU1. Plasmids carrying theileS2 gene were mosaic and also cocarry multiple other resistance determinants.

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