Anti-inflammatory Compound Shows Therapeutic Safety and Efficacy against Flavivirus Infection | Zendy

Fu-Kai Chuang | Zendy; ShihMing Huang | Zendy; ChingLen Liao | Zendy; AnRong Lee | Zendy; ShuPei Lien | Zendy; YuLung Chiu | Zendy; Tsung-Hsien Chang | Zendy; Pei-Ling Tsai | Zendy; Ren-Jye Lin | Zendy; ChihChin Shih | Zendy; YiJing Tsai | Zendy; GuJiun Lin | Zendy; Li-Chen Yen | Zendy

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Anti-inflammatory Compound Shows Therapeutic Safety and Efficacy against Flavivirus Infection

Author(s) -

Fu-Kai Chuang,

ShihMing Huang,

ChingLen Liao,

AnRong Lee,

ShuPei Lien,

YuLung Chiu,

Tsung-Hsien Chang,

Pei-Ling Tsai,

Ren-Jye Lin,

ChihChin Shih,

YiJing Tsai,

GuJiun Lin,

Li-Chen Yen

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00941-19

Subject(s) - zika virus , dengue virus , flavivirus , virology , dengue fever , japanese encephalitis , virus , outbreak , encephalitis , flaviviridae , medicine , biology , immunology , viral disease

Flaviviruses comprise several medically important viruses, including Japanese encephalitis virus, West Nile virus, dengue virus (DENV), yellow fever virus, and Zika virus (ZIKV). A large outbreak of DENV and ZIKV occurred recently, leading to many cases of illness and death. However, despite decades of effort, we have no clinically specific therapeutic drugs against DENV and ZIKV. Previous studies showed that inflammatory responses play a critical role in dengue and Zika virus pathogenesis.

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