Validation of a Dried Blood Spot Ceftriaxone Assay in Papua New Guinean Children with Severe Bacterial Infections | Zendy

Mispah Mukap | Zendy; Corin Sprod | Zendy; Nakapi Tefuarani | Zendy; Moses Laman | Zendy; Madhu PageSharp | Zendy; Sam Salman | Zendy; Brioni R. Moore | Zendy; Kevin T. Batty | Zendy; Timothy M. E. Davis | Zendy; Laurens Manning | Zendy

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Validation of a Dried Blood Spot Ceftriaxone Assay in Papua New Guinean Children with Severe Bacterial Infections

Author(s) -

Mispah Mukap,

Corin Sprod,

Nakapi Tefuarani,

Moses Laman,

Madhu PageSharp,

Sam Salman,

Brioni R. Moore,

Kevin T. Batty,

Timothy M. E. Davis,

Laurens Manning

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00940-18

Subject(s) - dried blood spot , ceftriaxone , medicine , antibiotics , pharmacokinetics , venous blood , anemia , new guinea , blood sampling , intensive care medicine , pharmacology , biology , microbiology and biotechnology , genetics , history , ethnology

Dried blood spot (DBS) antibiotic assays can facilitate pharmacokinetic (PK) studies in situations where venous blood sampling is logistically and/or ethically challenging. In this study, we aimed to demonstrate the validity of a DBS ceftriaxone assay in a PK study of children with severe illness from Papua New Guinea (PNG), a setting in which health care resources are limited and anemia is common.

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