Outer Membrane Interaction Kinetics of New Polymyxin B Analogs in Gram-Negative Bacilli | Zendy

Noushin Akhoundsadegh | Zendy; Corrie R. Belanger | Zendy; Robert E. W. Hancock | Zendy

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Outer Membrane Interaction Kinetics of New Polymyxin B Analogs in Gram-Negative Bacilli

Author(s) -

Noushin Akhoundsadegh,

Corrie R. Belanger,

Robert E. W. Hancock

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00935-19

Subject(s) - polymyxin , polymyxin b , bacterial outer membrane , acinetobacter baumannii , bacilli , microbiology and biotechnology , pseudomonas aeruginosa , biology , escherichia coli , context (archaeology) , lipopolysaccharide , chemistry , biochemistry , antibiotics , bacteria , paleontology , genetics , gene , endocrinology

Infections caused by drug-resistant Gram-negative bacilli are a severe global health threat, limiting effective drug choices for treatment. In this study, polymyxin analogs designed to have reduced nephrotoxicity, direct activity, and potentiating activity were assessed for inhibition and outer membrane interaction kinetics against wild-type (WT) and polymyxin or multidrug-resistant (MDR)Escherichia coli ,Pseudomonas aeruginosa ,Acinetobacter baumannii , andKlebsiella pneumoniae .

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