The tva (A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli | Zendy

Ana B. García-Martín | Zendy; Sybille Schwendener | Zendy; Vincent Perreten | Zendy

Open Access

The tva (A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli

Author(s) -

Ana B. García-Martín,

Sybille Schwendener,

Vincent Perreten

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00930-19

Subject(s) - escherichia coli , microbiology and biotechnology , staphylococcus aureus , biology , gene , antibiotics , genetics , bacteria

Thetva (A) gene suspected to confer resistance to pleuromutilins inBrachyspira hyodysenteriae was tested for functionality inEscherichia coli AG100A andStaphylococcus aureus RN4220. Expression of the clonedtva (A) gene conferred decreased susceptibility to pleuromutilin (P) and streptogramin A (SA ) antibiotics inE. coli and had a minor effect inS. aureus . The finding provides evidence of the direct association oftva (A) with the PSA resistance phenotype.

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