Pharmacokinetics and Bioequivalence Evaluation of Two Fixed-Dose Tablet Formulations of Dihydroartemisinin and Piperaquine in Vietnamese Subjects | Zendy

Nguyen Trong Chinh | Zendy; Nguyen Ngoc Quang | Zendy; Nguyễn Xuân Thành | Zendy; Bui Dai | Zendy; Jason P. Geue | Zendy; Russell S. Addison | Zendy; Thomas Travers | Zendy; Michael D. Edstein | Zendy

Open Access

Pharmacokinetics and Bioequivalence Evaluation of Two Fixed-Dose Tablet Formulations of Dihydroartemisinin and Piperaquine in Vietnamese Subjects

Author(s) -

Nguyen Trong Chinh,

Nguyen Ngoc Quang,

Nguyễn Xuân Thành,

Bui Dai,

Jason P. Geue,

Russell S. Addison,

Thomas Travers,

Michael D. Edstein

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00927-08

Subject(s) - bioequivalence , dihydroartemisinin , pharmacokinetics , piperaquine , vietnamese , medicine , pharmacology , mathematics , artemisinin , immunology , malaria , linguistics , philosophy , plasmodium falciparum

The two fixed-dose combinations of dihydroartemisinin and piperaquine (Artekin and Arterakine) were found to be bioinequivalent in healthy Vietnamese subjects. However, because the peak plasma concentrations and areas under the concentration-time curves of dihydroartemisinin and piperaquine were only marginally different between the two formulations, similar therapeutic efficacies are expected in the treatment of malaria infections.

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