Enhancement of Apoptosis of THP-1 Cells Infected withMycobacterium tuberculosisby Inhalable Microparticles and Relevance to Bactericidal Activity | Zendy

Awadh Bihari Yadav | Zendy; Amit Misra | Zendy

Open Access

Enhancement of Apoptosis of THP-1 Cells Infected withMycobacterium tuberculosisby Inhalable Microparticles and Relevance to Bactericidal Activity

Author(s) -

Awadh Bihari Yadav,

Amit Misra

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00925-07

Subject(s) - apoptosis , rifabutin , mycobacterium tuberculosis , microbiology and biotechnology , isoniazid , purinergic receptor , chemistry , bacteria , mycobacterium , antibiotics , intracellular , tuberculosis , biology , receptor , medicine , biochemistry , clarithromycin , genetics , pathology

The relevance of apoptosis to killing of intracellular Mycobacterium tuberculosis was studied with phorbol-differentiated THP-1 cells. Microparticles containing isoniazid and rifabutin induced intrinsic apoptosis and bacterial killing equivalent to that with dissolved drugs and maximally enhanced purinergic P2 receptor activity, while drug-free microparticles induced apoptosis via a different mechanism without killing bacteria.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research