Efficacy of the De Novo-Derived Antimicrobial Peptide WLBU2 against Oral Bacteria | Zendy

Karen F. Novak | Zendy; William J. Diamond | Zendy; Sreenatha Kirakodu | Zendy; Rebecca Peyyala | Zendy; Kimberly W. Anderson | Zendy; Ronald C. Montelaro | Zendy; Timothy A. Mietzner | Zendy

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Efficacy of the De Novo-Derived Antimicrobial Peptide WLBU2 against Oral Bacteria

Author(s) -

Karen F. Novak,

William J. Diamond,

Sreenatha Kirakodu,

Rebecca Peyyala,

Kimberly W. Anderson,

Ronald C. Montelaro,

Timothy A. Mietzner

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00924-06

Subject(s) - fusobacterium nucleatum , streptococcus gordonii , porphyromonas gingivalis , antimicrobial , microbiology and biotechnology , bacteria , biology , peptide , fusobacterium , streptococcaceae , antibiotics , bacteroides , biochemistry , genetics

The efficacy of a novel synthetic antimicrobial peptide (WLBU2) was evaluated against three oral microorganisms (grown planktonically): Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis. WLBU2 killed all three species, with F. nucleatum being the most susceptible. WLBU2 also reduced the bacterial burden of S. gordonii and F. nucleatum biofilms.

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