New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir | Zendy

Sunwen Chou | Zendy; L. Elizabeth Satterwhite | Zendy; Ronald J. Ercolani | Zendy

Open Access

New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir

Author(s) -

Sunwen Chou,

L. Elizabeth Satterwhite,

Ronald J. Ercolani

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00922-18

Subject(s) - ganciclovir , human cytomegalovirus , virology , drug resistance , biology , locus (genetics) , in vitro , cytomegalovirus , herpesviridae , pharmacology , gene , microbiology and biotechnology , virus , genetics , viral disease

Letermovir is a human cytomegalovirus (CMV) terminase inhibitor recently approved as prophylaxis in stem cell transplant recipients. In further studies of emerging drug resistance, a baseline laboratory CMV strain was serially propagated in cell culture under a combination of letermovir and ganciclovir.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research