A Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus | Zendy

Eleusa Maria Ferreira Rocha | Zendy; Guillermo GarcíaEffrón | Zendy; Steven Park | Zendy; David S. Perlin | Zendy

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A Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus

Author(s) -

Eleusa Maria Ferreira Rocha,

Guillermo GarcíaEffrón,

Steven Park,

David S. Perlin

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00917-07

Subject(s) - echinocandin , aspergillus fumigatus , microbiology and biotechnology , biology , aspergillus , drug resistance , echinocandins , antifungal , caspofungin , fluconazole

An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance inAspergillus fumigatus . The equivalent mutation inCandida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.

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