Open AccessA Ser678Pro Substitution in Fks1p Confers Resistance to Echinocandin Drugs in Aspergillus fumigatus
Author(s) -
Eleusa Maria Ferreira Rocha,
Guillermo GarcíaEffrón,
Steven Park,
David S. Perlin
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00917-07
Subject(s) - echinocandin , aspergillus fumigatus , microbiology and biotechnology , biology , aspergillus , drug resistance , echinocandins , antifungal , caspofungin , fluconazole
An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance inAspergillus fumigatus . The equivalent mutation inCandida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.