Open AccessComparative Antianaerobic Activities of Doripenem Determined by MIC and Time-Kill Analysis
Author(s) -
Kim Credito,
Lois M. Ednie,
Peter C. Appelbaum
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00910-07
Subject(s) - doripenem , ertapenem , meropenem , imipenem , carbapenem , microbiology and biotechnology , medicine , antibiotics , biology , antibiotic resistance
Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC50 of 0.125 μg/ml and an MIC90 of 1 μg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2× MIC after 48 h.