Repurposing Thiram and Disulfiram as Antibacterial Agents for Multidrug-Resistant Staphylococcus aureus Infections | Zendy

Timothy E. Long | Zendy

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Repurposing Thiram and Disulfiram as Antibacterial Agents for Multidrug-Resistant Staphylococcus aureus Infections

Author(s) -

Timothy E. Long

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00898-17

Subject(s) - staphylococcus aureus , vancomycin , microbiology and biotechnology , disulfiram , medicine , multiple drug resistance , antibiotics , pharmacology , biology , bacteria , genetics

Thiram and disulfiram were evaluated as antibacterial agents against multidrug-resistantStaphylococcus aureus . Against a 30-member panel comprised of vancomycin-susceptible, vancomycin-intermediate, and vancomycin-resistantS. aureus strains, the MIC90 values of the respective test agents were 4 and 16 μg/ml. Additional analyses revealed that thiram and disulfiram are rapid-acting bacteriostatic agents with narrow, Gram-positive-bacterium spectrum activity. Synergy studies further determined that disulfiram increases the vancomycin susceptibility of three clinical vancomycin-resistantS. aureus strainsin vitro , thus establishing a potential use in combination therapy.

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