Telithromycin and Quinupristin-Dalfopristin Induce Delayed Death in Plasmodium falciparum | Zendy

Diana Barthel | Zendy; Martin Schlitzer | Zendy; Gabriele Pradel | Zendy

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Telithromycin and Quinupristin-Dalfopristin Induce Delayed Death in Plasmodium falciparum

Author(s) -

Diana Barthel,

Martin Schlitzer,

Gabriele Pradel

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00892-07

Subject(s) - telithromycin , quinupristin , plasmodium falciparum , dalfopristin , medicine , microbiology and biotechnology , malaria , virology , antibiotics , antibacterial agent , biology , immunology , bacteria , vancomycin , genetics , staphylococcus aureus

Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum. Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of apicoplast translation processes.

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